Maximize research and production results with Pilot Scale Bioreactor

Pilot scale bioreactor with leading technology and flexibility

Optimizing bioprocessing outcomes with innovative engineering and precise regulation.

The ePILOTĀ® is made of stainless steel AISI 304 and 316L. It is a crucial tool in upstream processes, providing exceptional productivity in both cell culture and microbial fermentation. Its design, crafted to meet diverse client demands, prioritises efficient culture growth and offers various vessel sizes for seamless scale-up productions.

Integrating a PLC into our bioreactor improves bioprocessing success by providing flexible programming, ensuring a comprehensive understanding of each stage of the process.

Our pilot scale bioreactor features advanced monitoring systems. These systems enable the real-time tracking of crucial parameters like pH, pO2, temperature, and foam levels. This tracking ensures ideal conditions for the growth and development of cells and microorganisms.

Maximizing bioprocessing efficiency with pilot scale bioreactor

Modular vessel design
Advanced control system
Precision monitoring
Sterilization capabilities
Optimised agitation system

Key strategies for effective scalability in pilot scale bioreactors

TECNIC ePILOTĀ® bioreactor offers a unique solution in scalability and adaptability, allowing for the interchangeability of vessels1 between the cellular and microbial versions. Essential for laboratories and production plants, seeking flexibility in their cell culture and microbial fermentation processes.

With working volumes of 10, 20, 30, and 50 liters, the interchangeable vessels of the ePILOTĀ® facilitate the transition between different scales of production or research, without the need to invest in multiple systems. The bioreactor is dedicated to precision and adaptability, with real-time monitoring through integrated sensors.

Key components include: external jacket, sparger, overlay gas inlets, rupture disc, addition valves, and ports for sensors, sampling kit, a bottom valve and a front-integrated sight glass allows monitoring of crucial parameters like turbidity and agitation.

Vessels for Cell Culture

stainless steel cell culture vessel of pilot scale bioreactorstainless steel microbial culture vessel of pilot scale bioreactor

The cellular version of our ePILOTĀ® is an advanced system designed to optimize cell culture, offering unprecedented flexibility and efficiency for cellular applications. With working volumes of 10, 20, 30, and 50 liters and interchangeable vessels, the ePILOTĀ® seamlessly adapts to diverse research, development, and production needs.

This configuration encompasses comprehensive control of critical parameters vital for optimal cellular growth, including pH, temperature, dissolved oxygen, and foam. The jacketed vessel, available in a double-wall option, is equipped with a 2x pitched-blade impeller, its agitation features precisely governed by a Servomotor. Additionally, to further elevate functionality, the system can be augmented with optional features such as a microsparger for finer bubble generation and an AUTO SIP version for autonomous sterilization.

Vessels for Microbial Culture

The microbial version of our ePILOTĀ® bioreactor boosts the efficiency and flexibility of microbial fermentation processes. It ensures optimal growth conditions and process control for microbial applications. Equipped with interchangeable vessels, the pilot scale microbial bioreactor easily adapts to various scales, from small-scale research to larger production batches. Its advanced control systems and precise monitoring capabilities enable meticulous management of fermentation parameters, assuring high-quality outcomes.

It features a jacketed vessel and includes a Servomotor that controls three 6-blade Rushton impellers, providing superior mixing and aeration essential for effective microbial growth and product formation. The system can be upgraded with options like a microsparger for finer bubble generation, a dip pipe sparger for efficient gas delivery, AUTO SIP version, and off-gas analysis to fine-tune the cultivation environment.

Our range of bioreactors

elab essential
elab essential logo

198x335x200
Sizes (mm)

5
Weight (kg)

0,5 Ā· 1 Ā· 2 Ā· 5
Volumes (L)

Aluminium
Housing material

-
Scalable

Multi use
Single use
Vessels

Borosilicate glass
PP & PA 12
Vessel material

eOS
-
Software

Sensors
pH
Dissolved O2
Temperature sensor
Foam / Level sensor
External balance
-
-
-
-
-
-
-

4x fixed speed
-
Peristaltic pumps

Brushless
250
Motor (W)

elab advanced
elab advanced logo

460x817x550
Sizes (mm)

60
Weight (kg)

1 Ā· 2 Ā· 5 Ā· 10
Volumes (L)

Stainless steel
Housing material

Up to 12 vessels
Scalable

Multi use
Single Use
Vessels

Borosilicate glass
Stainless steel
Vessel material

eSCADA Advanced
eSCADA R&D
Software

Sensors
pH
Dissolved O2
Temperature sensor
Foam / Level sensor
External balance
Total cell density
Viable cell density
pCO2
ORP (Redox)
Off-gas analyzer
-
-

8x variable speed
-
Peristaltic pumps

Servomotor
400
Motor (W)

epilot bioreactor
epilot bioreactor logo

1200x2020x910
Sizes (mm)

-
Weight (kg)

10 Ā· 20 Ā· 30 Ā· 50
Volumes (L)

Stainless steel
Housing material

Interchangeable vessels
Scalable

Multi use
-
Vessels

Borosilicate glass
Stainless steel
Vessel material

eSCADA Advanced
eSCADA R&D
Software

Sensors
pH
Dissolved O2
Temperature sensor
Foam / Level sensor
External balance
Total cell density
Viable cell density
pCO2
ORP (Redox)
Off-gas analyzer
Pressure sensor
-

4x variable speed
-
Peristaltic pumps

Servomotor
400-750
Motor (W)

epilot bioreactor
epilot bioreactor logo

ā‰ˆ4455x6198x5125
Sizes (mm)

-
Weight (kg)

100 - 4000
Volumes (L)

Stainless steel
Housing material

-
Scalable

Multi use
-
Vessels

Borosilicate glass
Stainless steel
Vessel material

eSCADA Advanced
eSCADA R&D
Software

Sensors
pH
Dissolved O2
Temperature sensor
Foam / Level sensor
External balance
Total cell density
Viable cell density
pCO2
ORP (Redox)
Off-gas analyzer
Pressure sensor
-

2x variable speed
2x fixed speed
Peristaltic pumps

Asynchronous
190-19.000
Motor (W)

*When changing vessels, acquire a flexible hose kit for proper connection and optimal system operation.

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