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Bioreactor

ePROD

TECNIC’s production bioreactors are designed with a diameter/height ratio 1:3 for microbial fermentation and 1:2 for cell culture. This way, optimal culture conditions are given for both microbial and cellular testing.

These bioreactors are made of Stainless Steel 316L (for the wetted parts) and 304L (for the non-wetted parts) with working volumes from 100 to 2.000 L (or customized).

Due to its dimensions, this bioreactor includes stairs to reach de top of this. Each bioreactor includes pH, pO2, temperature and foam/level digital sensors (also are available optional digital sensors for redox, conductivity, total and viable cell density, biochemical parameters and pCO2).

Also includes a magnetic agitation with Rushton impellers for microbial fermentation and Pitched-Blade impellers for cell culture, a load cell to have an accurate weight control, a 360º spray ball for the Cleaning in Place (CIP) and Sterilization in Place (SIP) cycles, special additional valves designed by TECNIC and a double large sight glass to see the product status.

For a totally control of the process, it includes a control unit tower by TECNIC, which has a 15” capacity touch screen, gas supply systems and peristaltic pumps.

The control unit tower also has our TECNIC’s software named eSCADA which is based on a Supervising Control And Data Acquisition (SCADA) architecture and allows the management of basic process control parameters up to advanced recipes and report management. TECNIC offers its software in 3 different versions for this equipment: Basic, R&D+ and Advanced (more information in eSCADA page)

Datasheet

Microbial fermentation

  • Any type of microorganism.
  • Diameter/height ratio 1:3.
  • 2 mass flow controllers for air and oxygen (O2); Optional: nitrogen (N2).
  • Magnetic agitation.
  • Deflectors.
  • Rushton impellers.
  • Vessels made of Stainless Steel 316L (for the wetted parts) and 304L (for the non-wetted parts) with working volumes of 10, 20, 30 and 50 L. Double wall.
  • pH regulation with acid and base.
  • Special addition valves designed by TECNIC.
  • CIP/SIP cycles.

Cell Culture

  • Any type of cell line.
  • Diameter/height ratio 1:2.
  • 4 mass flow controllers for air, oxygen (O2), carbon dioxide (CO2) and nitrogen (N2).
  • Magnetic agitation.
  • Pitched-Blade impellers.
  • Vessels made of Stainless Steel 316L (for the wetted parts) and 304L (for the non-wetted parts) with working volumes of 10, 20, 30 and 50 L.
  • Double wall.
  • pH regulation with CO2 and base.
  • Special addition valves designed by TECNIC.
  • CIP/SIP cycles.
  • Optional: deflectors.