Cleaning Systems


TECNIC’s Cleaning Systems (CIP) are commonly used to clean bioreactors, fermenters, mix vessels, and other equipment used in the biotech, pharmaceutical and food and beverage manufacturing. 

This equipment achieves great results according to the Standards like United States Pharmacopeia (USP), Food and Drug Administration (FDA) or ISPE Guidelines by reducing the amount of water used, being environmentally responsible and energetically efficient.

CIP is performed to remove or obliterate previous mammalian cell culture batch components. It is used to remove in-process residues, control bioburden and reduce endotoxin levels within processing equipment and systems. 

The removal of residues is accomplished with a 6 phases CIP cycle

1. Pre-rinse

Waters the interior surface, removes most of the remaining residues, dissolves sugars and partially melts fats.

2. Caustic wash

Washes fats making them easier to remove.

3. Intermediate rinse

Water flushes out traces of detergent remaining.

4. Final rinse

With either DI, RO or city water to flush residual cleaning agents.

5. Sanitizing rinse

Helps to kill microorganisms before starting the next production.

6. DEP (Drying End Process)

Removes moisture remaining.

TECNIC designs and manufactures Full Automatic CIP’s with a tank for cleaning volumes up to 2.000L and a control unit tower with a 10” surface touch screen with our TECNIC’s software named eSCADA which is based on a Supervising Control And Data Acquisition (SCADA) architecture and allows the management of basic process control parameters up to advanced recipes and report management. TECNIC offers its software in 2 different versions for this equipment: Basic and Advanced (more information in the eSCADA page)

For this equipment, TECNIC offers two different possibilities: the single version which has only one detergent tank and the double version which has two different detergent tanks.

It is also available with a self-generating heat system just in case the user is needed to temper the product.