Scalability in biotech: from research to production

In the field of biotechnology, the successful transition from research discoveries to market production is a monumental challenge. This transition requires not only scientific innovation but also robust and scalable technological solutions. At TECNIC, we understand this critical need and strive to provide systems that facilitate efficient scalability from the laboratory to large-scale production. Our offerings extend to the downstream processing realm, where our Tangential Flow Filtration ā‡€Ā (TFF) equipment plays a pivotal role. The TECNIC TFF systems are engineered for post-bioprocessing and product recovery across biotech, pharmaceutical, and food industriesā€‹. They are designed to optimize the process, delivering high flow rates and high recoveries, adaptable to a variety of membrane materials and pore sizes availableā€‹ā€‹.

Together, our bioreactor and TFF systems form a comprehensive solution, ensuring a smooth transition from research to market production, embodying our commitment to driving innovation in biotechnology.

While challenges remain, such as production optimization and dosage control, the future of technologies based on viral vectors, VLPs, and AAVs is promising. These advancements are paving the way toward a new paradigm in medicine where diseases could be prevented, treated, and in some cases, even eradicated.

With the continued support of the scientific community and technological advancements, these innovative strategies are expected to play a crucial role in improving global health and combating the most devastating diseases of our time.

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Key features of our bioreactors and TFF that facilitate scalability

  1. Precise Parameter Control: Tight control of parameters essential for optimal cultivation, such as temperature, pH, and oxygen concentration, is crucial. Additionally, our TFF systems allow for the precise control of filtration processes, ensuring the concentration and purification of biomolecules are carried out efficiently and effectively.
  2. Advanced Automation: Automation solutions that enable real-time monitoring and control of the cultivation process, facilitating reproducibility and scalability of biotechnological processes. Our TFF systems also incorporate advanced automation features that streamline the monitoring and control of filtration operations, thus enhancing the overall process efficiency.
  3. Modular Design: TECNIC bioreactors feature a modular design that allows for efficient expansion and adaptation to changing production needs. Similarly, our TFF systems are designed with modularity in mind, allowing for a seamless integration with bioreactors and enabling an efficient scale-up of filtration processes as production demands evolve.
  4. Intuitive User Interface: A simple and functional user interface facilitates system operation, allowing quick adjustment to different production scales. The intuitive interface extends to our TFF systems, making the operation and monitoring of filtration processes straightforward and user-friendly.
  5. Expert Technical Support and Consultancy: Our team of experts provides technical support and consultancy to assist in the optimisation and scalability of processes. They have extensive knowledge in both bioreactor and TFF technologies, ensuring that you receive well-rounded support and consultancy for your bioproduction challenges

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Rushton impeller

The Rushton impeller, also known as the flat disk impeller. It emerged as a solution to the challenges of mixing and oxygenation in the biotechnology industry. Its innovative design was quickly recognized for its exceptional ability to generate turbulent flow, making it a standard in the sector for decades.

Pitch blade impeller

This component is crucial for optimizing mixing and mass transfer in cell culture processes. Its specific design facilitates homogeneous distribution of nutrients and gases, essential for maintaining cell viability and growth under optimal conditions.

Rushton impeller

Characterized by its radial blades mounted perpendicularly to the shaft, the Rushton impeller is engineered to provide high shear rates and excellent gas dispersion, which is particularly effective in microbial. In biotechnological applications involving bacteria and yeast, the Rushton impeller excels by ensuring homogeneous mixing and optimal gas distribution, even in high-density cultures.

Cassette

We understand the importance of flexibility and efficiency in laboratory processes. That's why our equipment is designed to be compatible with Cassette filters, an advanced solution for a variety of filtration applications. Although we do not manufacture the filters directly, our systems are optimized to take full advantage of the benefits that Cassette filters offer.

Cassette filters are known for their high filtration capacity and efficiency in separation, making them ideal for ultrafiltration, microfiltration, and nanofiltration applications. By integrating these filters into our equipment, we facilitate faster and more effective processes, ensuring high-quality results.

Our equipment, being compatible with Cassette filters, offers greater versatility and adaptability. This means you can choose the filter that best suits your specific needs, ensuring that each experiment or production process is carried out with maximum efficiency and precision.

Moreover, our equipment stands out for its 100% automation capabilities. Utilizing advanced proportional valves, we ensure precise control over differential pressure, transmembrane pressure, and flow rate. This automation not only enhances the efficiency and accuracy of the filtration process but also significantly reduces manual intervention, making our systems highly reliable and user-friendly.

Hollow Fiber

We recognize the crucial role of flexibility and efficiency in laboratory processes. That's why our equipment is meticulously designed to be compatible with Hollow Fiber filters, providing an advanced solution for a broad spectrum of filtration applications. While we don't directly manufacture these filters, our systems are finely tuned to harness the full potential of Hollow Fiber filters.

Hollow Fiber filters are renowned for their exceptional performance in terms of filtration efficiency and capacity. They are particularly effective for applications requiring gentle handling of samples, such as in cell culture and sensitive biomolecular processes. By integrating these filters with our equipment, we enable more efficient, faster, and higher-quality filtration processes.

What sets our equipment apart is its 100% automation capability. Through the use of sophisticated proportional valves, our systems achieve meticulous control over differential pressure, transmembrane pressure, and flow rate. This level of automation not only boosts the efficiency and precision of the filtration process but also significantly diminishes the need for manual oversight, rendering our systems exceptionally reliable and user-friendly.

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